Many inhalers that do not use chlorofluorocarbons (CFC) are already available for the treatment of asthma and chronic obstructive pulmonary disease. These products aren't necessarily "official" direct alternatives to CFC Metered Dose Inhalers, but may in many patients serve as a useful medication that could replace the need for a particular CFC Metered Dose Inhaler. FDA will determine official alternatives by using the criteria established through notice-and-comment rulemaking, as it has done with albuterol.
Information regarding FDA's approval of these inhalers is available here. As FDA approves new non-CFC inhalers, we will add that information to this page.
Drugs are listed in alphabetical order by active moiety, with specific brands available listed under each active moiety. What is an active moiety? An active moiety is the part of a drug that makes the drug work the way it does. Many different drug products may be marketed with the same active moiety.
Each drug name in the list below is linked to the drug’s regulatory history, including label, from Drugs@FDA.
- Tudorza Pressair (aclidinium bromide)
- ProAir Respiclick (albuterol sulfate inhalation powder)
Combivent Respimat (albuterol sulfate and ipratropium bromide)
Duoneb (albuterol sulfate and ipratropium bromide) Inhalation Solution
Symbicort (budesonide and formoterol fumarate) Inhalation Aerosol
Breo Ellipta (fluticasone furoate and vilanterol trifenatate)
Dulera (mometasone furoate and formoterol fumarate) Inhalation Aerosol
- Serevent Diskus (salmeterol xinafoate powder for inhalation)
ADVAIR Diskus (salmeterol xinafoate/fluticasone propionate powder for inhalation)
Anoro Ellipta (umeclidinium and vilanterol inhalation powder)
